The domain within your query sequence starts at position 163 and ends at position 346; the E-value for the 1io0 domain shown below is 1e-80.

VRNVVKGEKAKPVFEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKSL
ETNTHVKKFSLAATRSNDPVALAFAEMLKVNKTLKSLNVESNFITGTGILALVEALREND
TLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVR
KKRV

This is a PDB domain - please see the PDBSUM entry of 1io0 for further annotation